Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques
Identifieur interne : 000124 ( France/Analysis ); précédent : 000123; suivant : 000125Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques
Auteurs : Darryl Falzarano ; Emmie De Wit ; Angela L. Rasmussen ; Friederike Feldmann ; Atsushi Okumura ; Dana P. Scott ; Doug Brining ; Trenton Bushmaker ; Cynthia Martellaro ; Laura Baseler ; Arndt G. Benecke [France] ; Michael G. Katze ; Vincent J. Munster ; Heinz FeldmannSource :
- Nature Medicine [ 1078-8956 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (usage thérapeutique), Coronavirus (physiologie), Infections à coronavirus (traitement médicamenteux), Interféron alpha (usage thérapeutique), Macaca mulatta, Protéines recombinantes (usage thérapeutique), Ribavirine (usage thérapeutique), Réaction de polymérisation en chaine en temps réel, Réplication virale.
- MESH :
- physiologie : Coronavirus.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux, Interféron alpha, Protéines recombinantes, Ribavirine.
- Animaux, Macaca mulatta, Réaction de polymérisation en chaine en temps réel, Réplication virale.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (therapeutic use), Coronavirus (physiology), Coronavirus Infections (drug therapy), Interferon alpha-2, Interferon-alpha (therapeutic use), Macaca mulatta, Real-Time Polymerase Chain Reaction, Recombinant Proteins (therapeutic use), Ribavirin (therapeutic use), Virus Replication.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Interferon-alpha, Recombinant Proteins, Ribavirin.
- drug therapy : Coronavirus Infections.
- physiology : Coronavirus.
- Animals, Interferon alpha-2, Macaca mulatta, Real-Time Polymerase Chain Reaction, Virus Replication.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) has killed ∼50% of individuals known to be infected, making understanding its mechanisms of transmission and pathogenesis and identifying candidate treatments a high priority. Heinz Feldmann, Vincent J. Munster and Michael G. Katze and their colleagues now report that treating MERS-CoV-infected rhesus macaques with interferon-α2b and ribavirin reduced virus replication and infection severity, suggesting the potential use of this combination for the clinical treatment of infected humans.
The online version of this article (doi:10.1038/nm.3362) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nm.3362
PubMed: 24013700
PubMed Central: 4093902
Affiliations:
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PMC:4093902Le document en format XML
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Benecke</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.34477.33</institution-id><institution-id institution-id-type="ISNI">0000000122986657</institution-id><institution>Department of Microbiology,</institution><institution>University of Washington,</institution></institution-wrap>Seattle, Washington USA</nlm:aff><wicri:noCountry code="subfield">Washington USA</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff6">Université Pierre et Marie Curie, Centre National de la Recherche Scientifique, Paris, UMR7224 France</nlm:aff><orgName type="university">Université Pierre-et-Marie-Curie</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.34477.33</institution-id><institution-id institution-id-type="ISNI">0000000122986657</institution-id><institution>Department of Microbiology,</institution><institution>University of Washington,</institution></institution-wrap>Seattle, Washington USA</nlm:aff><wicri:noCountry code="subfield">Washington USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.34477.33</institution-id><institution-id institution-id-type="ISNI">0000000122986657</institution-id><institution>Washington National Primate Research Center, University of Washington,</institution></institution-wrap>Seattle, Washington USA</nlm:aff><wicri:noCountry code="subfield">Washington USA</wicri:noCountry></affiliation></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.419681.3</institution-id><institution-id institution-id-type="ISNI">0000 0001 2164 9667</institution-id><institution>Division of Intramural Research,</institution><institution>Virus Ecology Unit, Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories,</institution></institution-wrap>Hamilton, Montana USA</nlm:aff><wicri:noCountry code="subfield">Montana USA</wicri:noCountry></affiliation></author><author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.419681.3</institution-id><institution-id institution-id-type="ISNI">0000 0001 2164 9667</institution-id><institution>Division of Intramural Research,</institution><institution>Disease Modeling and Transmission Unit, Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories,</institution></institution-wrap>Hamilton, Montana USA</nlm:aff><wicri:noCountry code="subfield">Montana USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.21613.37</institution-id><institution-id institution-id-type="ISNI">0000 0004 1936 9609</institution-id><institution>Department of Medical Microbiology,</institution><institution>University of Manitoba,</institution></institution-wrap>Winnipeg, Manitoba Canada</nlm:aff><wicri:noCountry code="subfield">Manitoba Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">Nature Medicine</title><idno type="ISSN">1078-8956</idno><idno type="eISSN">1546-170X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus (physiology)</term><term>Coronavirus Infections (drug therapy)</term><term>Interferon alpha-2</term><term>Interferon-alpha (therapeutic use)</term><term>Macaca mulatta</term><term>Real-Time Polymerase Chain Reaction</term><term>Recombinant Proteins (therapeutic use)</term><term>Ribavirin (therapeutic use)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (usage thérapeutique)</term><term>Coronavirus (physiologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Interféron alpha (usage thérapeutique)</term><term>Macaca mulatta</term><term>Protéines recombinantes (usage thérapeutique)</term><term>Ribavirine (usage thérapeutique)</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Réplication virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Interferon-alpha</term><term>Recombinant Proteins</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Interféron alpha</term><term>Protéines recombinantes</term><term>Ribavirine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Interferon alpha-2</term><term>Macaca mulatta</term><term>Real-Time Polymerase Chain Reaction</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Macaca mulatta</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">The Middle East respiratory syndrome coronavirus (MERS-CoV) has killed ∼50% of individuals known to be infected, making understanding its mechanisms of transmission and pathogenesis and identifying candidate treatments a high priority. Heinz Feldmann, Vincent J. Munster and Michael G. Katze and their colleagues now report that treating MERS-CoV-infected rhesus macaques with interferon-α2b and ribavirin reduced virus replication and infection severity, suggesting the potential use of this combination for the clinical treatment of infected humans.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nm.3362) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stockman, Lj" uniqKey="Stockman L">LJ Stockman</name></author><author><name sortKey="Bellamy, R" uniqKey="Bellamy R">R Bellamy</name></author><author><name sortKey="Garner, P" uniqKey="Garner P">P Garner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soo, Yo" uniqKey="Soo Y">YO Soo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, Jc" uniqKey="Ho J">JC Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Booth, Cm" uniqKey="Booth C">CM Booth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Ks" uniqKey="Chan K">KS Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loutfy, Mr" uniqKey="Loutfy M">MR Loutfy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, E" uniqKey="Thomas E">E Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarasin Filipowicz, M" uniqKey="Sarasin Filipowicz M">M Sarasin-Filipowicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menshykau, D" uniqKey="Menshykau D">D Menshykau</name></author><author><name sortKey="Kraemer, C" uniqKey="Kraemer C">C Kraemer</name></author><author><name sortKey="Iber, D" uniqKey="Iber D">D Iber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Teng, H" uniqKey="Teng H">H Teng</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, Ac" uniqKey="White A">AC White</name></author><author><name sortKey="Lavine, Kj" uniqKey="Lavine K">KJ Lavine</name></author><author><name sortKey="Ornitz, Dm" uniqKey="Ornitz D">DM Ornitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, Ac" uniqKey="White A">AC White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cigna, N" uniqKey="Cigna N">N Cigna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fitch, Pm" uniqKey="Fitch P">PM Fitch</name></author><author><name sortKey="Howie, Se" uniqKey="Howie S">SE Howie</name></author><author><name sortKey="Wallace, Wa" uniqKey="Wallace W">WA Wallace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pogach, Ms" uniqKey="Pogach M">MS Pogach</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author><author><name sortKey="Millien, G" uniqKey="Millien G">G Millien</name></author><author><name sortKey="Ramirez, Mi" uniqKey="Ramirez M">MI Ramirez</name></author><author><name sortKey="Williams, Mc" uniqKey="Williams M">MC Williams</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brining, Dl" uniqKey="Brining D">DL Brining</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kobasa, D" uniqKey="Kobasa D">D Kobasa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noth, S" uniqKey="Noth S">S Noth</name></author><author><name sortKey="Brysbaert, G" uniqKey="Brysbaert G">G Brysbaert</name></author><author><name sortKey="Benecke, A" uniqKey="Benecke A">A Benecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becavin, C" uniqKey="Becavin C">C Bécavin</name></author><author><name sortKey="Tchitchek, N" uniqKey="Tchitchek N">N Tchitchek</name></author><author><name sortKey="Mintsa Eya, C" uniqKey="Mintsa Eya C">C Mintsa-Eya</name></author><author><name sortKey="Lesne, A" uniqKey="Lesne A">A Lesne</name></author><author><name sortKey="Benecke, A" uniqKey="Benecke A">A Benecke</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><noCountry><name sortKey="Baseler, Laura" sort="Baseler, Laura" uniqKey="Baseler L" first="Laura" last="Baseler">Laura Baseler</name><name sortKey="Brining, Doug" sort="Brining, Doug" uniqKey="Brining D" first="Doug" last="Brining">Doug Brining</name><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name><name sortKey="Martellaro, Cynthia" sort="Martellaro, Cynthia" uniqKey="Martellaro C" first="Cynthia" last="Martellaro">Cynthia Martellaro</name><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name><name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name><name sortKey="Rasmussen, Angela L" sort="Rasmussen, Angela L" uniqKey="Rasmussen A" first="Angela L" last="Rasmussen">Angela L. Rasmussen</name><name sortKey="Scott, Dana P" sort="Scott, Dana P" uniqKey="Scott D" first="Dana P" last="Scott">Dana P. Scott</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Benecke, Arndt G" sort="Benecke, Arndt G" uniqKey="Benecke A" first="Arndt G" last="Benecke">Arndt G. Benecke</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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